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PYY 3-36 crosses the bloodbrain-barrier 26 and inhibits food intake via its interactions with Y2-R in brain areas that regulate energy homeostasis, including the ARC of the hypothalamus and the AP and NTS of the hindbrain 27,28,29,30
In Holschers reading, that is the expected outcome, not a surprise
All five new smoothies on the Smoothie King GLP-1 menu are designed to help with hydration and side effects of taking the weight loss drugs, which include digestive issues, bloating, fatigue, and loss of appetite
Some people with UC struggle with unintentional weight loss during flares
Based on that pacing, I would project an NDA filing in late 2026 and a possible approval window in 2027 if results hold
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